环丙沙星对家兔特异性免疫反应的影响。
Effect of ciprofloxacin on specific immune response in rabbits.
作者信息
Jayakumar K, Krishnappa G, Sastry K N V, Narayana K
机构信息
Department of Pharmacology, Microbiology, Veterinary College, Hebbal, Bangalore 560 024, India.
出版信息
Indian J Exp Biol. 2002 Jan;40(1):111-4.
Ciprofloxacin (10 mg/kg body weight, iv, twice daily for 4 days) failed to alter specific antibody titres, total immunoglobulin concentration, total serum protein concentration, total leukocyte count, lymphocyte percentage, phagocytic index and skin thickness in DNCB skin sensitivity test against Brucella plain killed antigen in New Zealand White rabbits. It can be concluded that ciprofloxacin at the dose and duration employed did not adversely affect specific immune response in normal rabbits.
环丙沙星（10毫克/千克体重，静脉注射，每日两次，共4天）未能改变新西兰白兔针对布鲁氏菌灭活抗原的二硝基氯苯皮肤敏感性试验中的特异性抗体滴度、总免疫球蛋白浓度、总血清蛋白浓度、白细胞总数、淋巴细胞百分比、吞噬指数和皮肤厚度。可以得出结论，在所采用的剂量和疗程下，环丙沙星对正常兔子的特异性免疫反应没有不利影响。
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