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染料木黄酮的药理活性,一种来自大豆(大豆)的异黄酮:第二部分——抗胆固醇活性、对骨质疏松症和更年期症状的影响。

Pharmacological activities of Genistein, an isoflavone from soy (Glycine max): part II--anti-cholesterol activity, effects on osteoporosis & menopausal symptoms.

作者信息

Suthar A C, Banavalikar M M, Biyani M K

机构信息

Ajanta Pharma Ltd., Research Centre, Ajanta House, 98, Govt. Industrial Area, Charkop, Kandivali (West), Mumbai 400 067, India.

出版信息

Indian J Exp Biol. 2001 Jun;39(6):520-5.

PMID:12562012
Abstract

Phytoestrogens represent a family of plant compounds such as isoflavones, flavones and lignans. A wide range of commonly consumed foods contains appreciable amounts of different phytoestrogens such as isoflavones and lignans. Soy and its products are particularly good sources of isoflavones and lignans. The evidence reviewed here represents the beneficial effects of most potential and promising isoflavone, Genistein in various types of diseases such as osteoporosis, cardiovascular diseases, menopausal symptoms by accumulating evidence from molecular and cellular biology experiments, animal studies, and, to a limited extent, human clinical trials. This review suggests that phytoestrogens may potentially confer health benefits related to various diseases such as cardiovascular disorder, menopausal symptoms, and osteoporosis.

摘要

植物雌激素是一类植物化合物,如异黄酮、黄酮和木脂素。许多常见的食用食物都含有相当数量的不同植物雌激素,如异黄酮和木脂素。大豆及其制品是异黄酮和木脂素的特别良好来源。本文综述的证据通过分子和细胞生物学实验、动物研究以及在有限程度上的人体临床试验积累的证据,展示了最具潜力和前景的异黄酮染料木黄酮在各种疾病(如骨质疏松症、心血管疾病、更年期症状)中的有益作用。本综述表明,植物雌激素可能潜在地带来与各种疾病(如心血管疾病、更年期症状和骨质疏松症)相关的健康益处。

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1
Pharmacological activities of Genistein, an isoflavone from soy (Glycine max): part II--anti-cholesterol activity, effects on osteoporosis & menopausal symptoms.染料木黄酮的药理活性,一种来自大豆(大豆)的异黄酮:第二部分——抗胆固醇活性、对骨质疏松症和更年期症状的影响。
Indian J Exp Biol. 2001 Jun;39(6):520-5.
2
Pharmacological activities of Genistein, an isoflavone from soy (Glycine max): part I--anti-cancer activity.染料木黄酮(一种来自大豆(Glycine max)的异黄酮)的药理活性:第一部分——抗癌活性。
Indian J Exp Biol. 2001 Jun;39(6):511-9.
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[Phytoestrogens].[植物雌激素]
Zentralbl Gynakol. 2003 Jun;125(6):195-201. doi: 10.1055/s-2003-42601.
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Phytoestrogens and cardiovascular disease.植物雌激素与心血管疾病
J Br Menopause Soc. 2006 Jun;12(2):49-56. doi: 10.1258/136218006777525776.
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Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence.临床综述97:膳食植物雌激素对健康的潜在益处:临床、流行病学及机制证据综述
J Clin Endocrinol Metab. 1998 Jul;83(7):2223-35. doi: 10.1210/jcem.83.7.4752.
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Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer?亚麻籽及其木脂素与大豆及其异黄酮的组合能否降低大豆及其异黄酮对已确诊乳腺癌的生长刺激作用?
Mol Nutr Food Res. 2007 Jul;51(7):845-56. doi: 10.1002/mnfr.200600218.
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A review of the clinical effects of phytoestrogens.植物雌激素临床疗效综述。
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Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits.简单化的异黄酮——染料木黄酮对β型雌激素受体的激动活性介导了它们的健康益处。
Med Hypotheses. 2006;66(6):1093-114. doi: 10.1016/j.mehy.2004.11.046. Epub 2006 Mar 2.
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Equol but not genistein improves early metaphyseal fracture healing in osteoporotic rats.雌马酚而非染料木黄酮可改善骨质疏松大鼠早期干骺端骨折的愈合。
Planta Med. 2009 Apr;75(5):459-65. doi: 10.1055/s-0029-1185380. Epub 2009 Feb 24.
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Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities.大豆异黄酮的提取、纯化及其雌激素活性表征
J Agric Food Chem. 2007 Aug 22;55(17):6940-50. doi: 10.1021/jf0708903. Epub 2007 Jul 21.

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