Efron Daryl, Hiscock Harriet, Sewell Jillian R, Cranswick Noel E, Vance Alasdair L A, Tyl Yvonne, Luk Ernest S L
Centre for Community Child Health, Royal Children's Hospital, Melbourne, Australia.
Pediatrics. 2003 Feb;111(2):372-5. doi: 10.1542/peds.111.2.372.
To describe the pattern of prescribing of psychotropic medications for Australian children.
Australia-wide cross-sectional postal survey conducted in 2000.
All registered general pediatricians and child and adolescent psychiatrists.
The survey was completed by 435 general pediatricians and 187 child and adolescent psychiatrists (response rates 72% and 70%, respectively). Stimulants and clonidine were the most frequently prescribed medications. Seventy-two percent of practitioners reported that they had prescribed a combination of medications. Frequent combinations included a stimulant and clonidine (64% of pediatricians, 51% of child psychiatrists) and a stimulant and a selective serotonin reuptake inhibitor (SSRI; 29% of pediatricians, 36% of child psychiatrists). Pediatricians were more likely than child psychiatrists to report prescribing clonidine for sleep problems (67% vs 36%). Child psychiatrists were more likely than pediatricians to report prescribing SSRIs (93% vs 75%) and mood stabilizers (45% vs 11%) for depression, and SSRIs (74% vs 50%) and tricyclic antidepressants (37% vs 12%) for obsessive compulsive disorder. Off-label prescribing (indication or age not included in the product information) was reported by 40%. Over 5% of practitioners in this study had prescribed clonidine, methylphenidate, dexamphetamine, and typical neuroleptics for children under 3 years of age.
A broad range of psychotropic medications are being prescribed for Australian children, with some medication groups being prescribed frequently. Combinations of psychotropic medications are used regularly, and there is some prescribing for very young children. The safety and efficacy of several of the agents prescribed have not been adequately researched in children. There is an urgent need for pediatric psychopharmacology research to inform current prescribing practice.
描述澳大利亚儿童精神类药物的处方模式。
2000年在澳大利亚全国范围内开展的横断面邮政调查。
所有注册的普通儿科医生以及儿童和青少年精神科医生。
435名普通儿科医生和187名儿童和青少年精神科医生完成了调查(回复率分别为72%和70%)。兴奋剂和可乐定是最常开具的药物。72%的从业者报告称他们曾联合使用药物。常见的联合用药包括兴奋剂与可乐定(64%的儿科医生、51%的儿童精神科医生)以及兴奋剂与选择性5-羟色胺再摄取抑制剂(SSRI;29%的儿科医生、36%的儿童精神科医生)。儿科医生比儿童精神科医生更有可能报告为睡眠问题开具可乐定(67%对36%)。儿童精神科医生比儿科医生更有可能报告为抑郁症开具SSRI(93%对75%)和情绪稳定剂(45%对11%),以及为强迫症开具SSRI(74%对50%)和三环类抗抑郁药(37%对12%)。40%的人报告有超说明书用药情况(产品信息中未包含的适应证或年龄)。在本研究中,超过5%的从业者曾为3岁以下儿童开具可乐定、哌甲酯、右旋苯丙胺和典型抗精神病药。
澳大利亚儿童正在使用多种精神类药物,一些药物组的使用频率较高。精神类药物经常联合使用,并且存在为幼儿开药的情况。所开具的几种药物在儿童中的安全性和有效性尚未得到充分研究。迫切需要开展儿科精神药理学研究,为当前的处方实践提供依据。