Safer D J
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Child Adolesc Psychopharmacol. 1997;7(4):267-74. doi: 10.1089/cap.1997.7.267.
The active (1994) and closed (1988 to 1992) outpatient records of youths seen in four separate community mental health centers (CMHC) in Baltimore County, Maryland were reviewed in mid-1994 to document recent changes in the medication-prescribing practices of local child psychiatrists. Inpatient summaries of previously hospitalized CMHC youths were also reviewed to supplement the outpatient medication assessment with hospital data. This regional survey of medication treatments in child psychiatry revealed that, during the half decade before 1994, there was an increase in overall psychotropic medication treatment, multiple concurrent medication treatments (polypharmacy), and antidepressant treatment with serotonin reuptake inhibitors (SRIs). Inpatient youths were consistently prescribed more psychotropic medications and diagnosed more frequently with major depressive disorder than outpatients. Medications typically used to first treat mood disorders became the predominant medication prescribed for both outpatients and inpatients by child psychiatrists in 1994, leading to a proportional decline in prescribed stimulant treatment. The shift from tricyclic antidepressants to SRI antidepressants in the 1990s by child psychiatrists matches the same recent practice shift by adult psychiatrists. Likewise, the increased prescription of drugs to treat mood disorders and the increased rate of polypharmacy notable of late among child psychiatrists now also mirrors adult psychiatry practice. Wide geographic variations in neuroleptic and antidepressant medication patterns were noted, even among facilities in the same metropolitan region. After psychiatric hospitalization, most youths who continued treatment at a CMHC outpatient clinic discontinued their inpatient medications within 3 months; the sole exception were children who had been placed on psychostimulants.
1994年年中,对马里兰州巴尔的摩县四个独立社区心理健康中心(CMHC)接待的青少年的活跃(1994年)和已结束(1988年至1992年)门诊记录进行了审查,以记录当地儿童精神科医生用药处方实践的近期变化。还审查了CMHC之前住院青少年的住院摘要,以用医院数据补充门诊用药评估。这项儿童精神病学药物治疗的区域调查显示,在1994年之前的五年中,精神otropic药物的总体治疗、多种同时进行的药物治疗(多药治疗)以及使用5-羟色胺再摄取抑制剂(SRI)的抗抑郁治疗均有所增加。住院青少年比门诊患者一直被开更多的精神otropic药物,并且被诊断为重度抑郁症的频率更高。1994年,儿童精神科医生通常用于首次治疗情绪障碍的药物成为门诊患者和住院患者开出的主要药物,导致处方兴奋剂治疗的比例下降。20世纪90年代儿童精神科医生从三环类抗抑郁药向SRI抗抑郁药的转变与成人精神科医生近期的相同实践转变相匹配。同样,儿童精神科医生最近增加的治疗情绪障碍药物的处方和多药治疗率的增加现在也反映了成人精神病学实践。即使在同一大都市地区的医疗机构之间,也注意到抗精神病药物和抗抑郁药物模式存在广泛的地理差异。在精神病住院治疗后,大多数在CMHC门诊诊所继续治疗的青少年在3个月内停用了住院期间的药物;唯一的例外是服用精神兴奋剂的儿童。