Gudkov Andrei V, Komarova Elena A
Department of Molecular Biology, NC20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
Nat Rev Cancer. 2003 Feb;3(2):117-29. doi: 10.1038/nrc992.
Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against cancer. Rational and effective use of its killing power depends on understanding IR-mediated responses at the molecular, cellular and tissue levels. Tumour cells frequently acquire defects in the molecular regulatory mechanisms of the response to IR, which sensitizes them to radiation therapy. One of the key molecules involved in a cell's response to IR is p53. Understanding these mechanisms indicates new rational approaches to improving cancer treatment by IR.
电离辐射（IR）已被证明是对抗癌症的一种强有力的医学治疗手段。合理有效地利用其杀伤能力取决于在分子、细胞和组织水平上理解IR介导的反应。肿瘤细胞经常在对IR反应的分子调节机制中出现缺陷，这使它们对放射治疗敏感。细胞对IR反应所涉及的关键分子之一是p53。理解这些机制为通过IR改善癌症治疗指明了新的合理方法。
