Perussi Mário R, Denardin Odilon Vitor P, Fava Antonio Sérgio, Rapoport Abrão
Serviço de Cirurgia de Cabeça e Pescoço, Hospital Heliópolis, São Paulo, SP, Brasil.
Rev Assoc Med Bras (1992). 2002 Oct-Dec;48(4):341-4. doi: 10.1590/s0104-42302002000400041. Epub 2003 Jan 28.
To assess the influence of sex and primary tumor location on the outcome of mouth cancer in elderly patients.
A retrospective study of 1,440 patients with squamous cell carcinoma of mouth in the Head and Neck Department of Heliópolis Hospital, São Paulo during 1978-1997 period. There were 562 elderly patients (aged 60 or more years, according to WHO criteria for developing countries) and 878 patients younger than 60 years old. The variables sex, location of the tumor and life time after detection were compared between the two groups of patients. The chi squared test (x2 ) was used for statistical analysis with a 0.05 significance level (confidence interval of 95%).
The frequency of the mouth cancer in elderly patients remained stable in the studied period (39,5% in 1978-87 versus 38.2% in 1988-1997). The male/female ratio in squamous cell carcinoma of the oral cavity changed from 3:1 before 60 years old to 8:1 after this age. There was a predominance in buccal mucosa (56%) and palate (47%) in aged people when compared with the tumors of younger patients preferentially in floor/tongue (67%) and tongue (62%). No differences were found in the percentage of deceased patients before the beginning of therapeutic procedures (11.6% versus 10.5% in younger) or in the percentages of survivors, in different periods (6 months the five years).
A higher frequency of women with mouth cancer was observed in the elderly patients. The upper floor of the mouth site was more frequent in the patients aged 60 years or more while the inferior location (tongue and floor) were more frequent in patients under 60. The observed differences in relation to patient's sex and tumor location did not influence outcome in mouth cancer patients.
评估性别和原发肿瘤位置对老年口腔癌患者预后的影响。
对圣保罗埃利奥波利斯医院头颈科1978年至1997年期间的1440例口腔鳞状细胞癌患者进行回顾性研究。其中有562例老年患者（根据世界卫生组织针对发展中国家的标准，年龄在60岁及以上）和878例年龄小于60岁的患者。比较两组患者的性别、肿瘤位置和确诊后的生存时间等变量。采用卡方检验（x²）进行统计分析，显著性水平为0.05（95%置信区间）。
在研究期间，老年患者口腔癌的发病率保持稳定（1978 - 1987年为39.5%，1988 - 1997年为38.2%）。口腔鳞状细胞癌的男女比例在60岁之前为3:1，60岁之后变为8:1。与年轻患者的肿瘤主要发生在口底/舌（67%）和舌（62%）相比，老年患者中颊黏膜（56%）和腭部（47%）的肿瘤更为多见。在治疗程序开始前死亡患者的百分比（年轻患者为10.5%，老年患者为11.6%）以及不同时期（6个月至5年）的存活患者百分比方面，未发现差异。
在老年患者中观察到患口腔癌的女性比例更高。60岁及以上患者口腔上部位置的肿瘤更为常见，而60岁以下患者中下部位置（舌和口底）的肿瘤更为常见。观察到的患者性别和肿瘤位置差异并未影响口腔癌患者的预后。
