Takahashi Tsutomu, Suzuki Michio, Kawasaki Yasuhiro, Kurokawa Kenzo, Hagino Hirofumi, Yamashita Ikiko, Zhou Shi-Yu, Nohara Shigeru, Nakamura Kazue, Seto Hikaru, Kurachi Masayoshi
Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Eur Arch Psychiatry Clin Neurosci. 2002 Dec;252(6):268-77. doi: 10.1007/s00406-002-0392-3.
Lack of normal structural asymmetry of the anterior cingulate gyrus (ACG) in patients with schizophrenia has been reported in our previous study. However, to our knowledge, no morphological studies of the brain have examined changes in ACG volume in patients with schizotypal features. We investigated the volume of the gray matter and the white matter of the ACG by three-dimensional magnetic resonance imaging (MRI) in 24 patients who met the ICD-10 criteria for schizotypal disorder (12 males, 12 females) in comparison with 48 age- and gender-matched healthy control subjects (24 males, 24 females) and 40 patients with schizophrenia (20 males, 20 females). As we reported previously, right ACG gray matter volume was significantly reduced in the female patients with schizophrenia compared with the female controls. On the other hand, the gray and white matter volume of the ACG in the patients with schizotypal disorder did not differ significantly from the values in the healthy controls or the patients with schizophrenia. However, the female patients with schizotypal disorder showed a lack of right-greater-than-left asymmetry of the ACG gray and white matter found in the female controls. These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities.
我们之前的研究报道过，精神分裂症患者前扣带回（ACG）缺乏正常的结构不对称性。然而，据我们所知，尚无针对具有分裂型特征患者脑ACG体积变化的形态学研究。我们通过三维磁共振成像（MRI）对24例符合ICD - 10分裂型障碍标准的患者（12例男性，12例女性）进行了研究，将其与48例年龄和性别匹配的健康对照者（24例男性，24例女性）以及40例精神分裂症患者（20例男性，20例女性）的ACG灰质和白质体积进行比较。正如我们之前所报道的，与女性对照者相比，女性精神分裂症患者右侧ACG灰质体积显著减少。另一方面，分裂型障碍患者ACG的灰质和白质体积与健康对照者或精神分裂症患者的值相比，无显著差异。然而，分裂型障碍女性患者缺乏女性对照者中所发现的ACG灰质和白质右侧大于左侧的不对称性。这些结果表明，分裂型和精神分裂症患者至少在部分程度上存在相同的脑不对称异常。
