Tsunoda Masahiko, Kawasaki Yasuhiro, Matsui Mie, Tonoya Yasuhiro, Hagino Hirofumi, Suzuki Michio, Seto Hikaru, Kurachi Masayoshi
Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, Japan.
Eur Arch Psychiatry Clin Neurosci. 2005 Apr;255(2):104-10. doi: 10.1007/s00406-004-0540-z. Epub 2004 Nov 12.
The exploratory eye movements of schizophrenia patients and their relatives have been shown to differ from those of patients without schizophrenia and healthy controls. However the mechanism of exploratory eye movement disturbances in schizophrenia patients remains elusive. We investigated the relationship between the exploratory eye movements and brain morphology in 39 schizophrenia spectrum patients. Voxel-based morphometric analysis on three-dimensional magnetic resonance imaging was conducted by means of statistical parametric mapping 99. The decrease in the responsive search score, which is the total number of sections on which the eyes fixed in response to questioning in a comparison task, was significantly correlated with the decreased gray matter in the right frontal eye field (rFEF) including the right supplementary eye field (rSEF), right parietal eye field (rPEF), and right inferior frontal region. These results suggest that disturbance in exploratory eye movement in schizophrenia spectrum patients may be related to neural network dysfunction in FEF, SEF and PEF, which are the eye movement related areas, and in the inferior frontal region that may be related to information organization.
已证明精神分裂症患者及其亲属的探索性眼球运动与无精神分裂症患者及健康对照者不同。然而，精神分裂症患者探索性眼球运动障碍的机制仍不清楚。我们研究了39例精神分裂症谱系患者的探索性眼球运动与脑形态之间的关系。通过统计参数映射99对三维磁共振成像进行基于体素的形态学分析。反应性搜索分数的降低，即比较任务中眼睛对提问做出反应时固定注视的切片总数，与右侧额叶眼区（rFEF）包括右侧辅助眼区（rSEF）、右侧顶叶眼区（rPEF）和右侧额下区域灰质的减少显著相关。这些结果表明，精神分裂症谱系患者探索性眼球运动的障碍可能与眼球运动相关区域FEF、SEF和PEF以及可能与信息组织相关的额下区域的神经网络功能障碍有关。
