Boonpucknavig Vijitr, Soontornniyomkij Virawudh
Department of Pathology, Bangkok General Hospital, Bangkok, Thailand.
Semin Nephrol. 2003 Jan;23(1):88-106. doi: 10.1053/snep.2003.50008.
Renal diseases unique to the tropics are those that occur in association with infectious diseases including dengue hemorrhagic fever, typhoid fever, shigellosis, leptospirosis, lepromatous leprosy, malaria, opisthorchiasis, and schistosomiasis. These renal complications can be classified on the basis of their clinical and pathologic characteristics into acute transient reversible glomerulonephritis, chronic progressive irreversible glomerulonephritis, amyloidosis, and acute renal failure (ARF) resulting from acute tubular necrosis, acute tubulointerstitial nephritis, and thrombotic microangiopathy. Certain primary glomerular diseases including immunoglobulin (Ig) M nephropathy and focal segmental and global glomerulosclerosis are prevalent in some tropical countries. Renal complications of venomous snakebites also are common in the tropics. This article discusses and summarizes important works in the literature in respect to the clinical syndromes, pathologic features, and pathogenesis of tropical renal diseases both in humans and experimental animal models.
热带地区特有的肾脏疾病是那些与传染病相关的疾病，包括登革出血热、伤寒、志贺菌病、钩端螺旋体病、瘤型麻风、疟疾、华支睾吸虫病和血吸虫病。这些肾脏并发症可根据其临床和病理特征分为急性短暂可逆性肾小球肾炎、慢性进行性不可逆性肾小球肾炎、淀粉样变性以及由急性肾小管坏死、急性肾小管间质性肾炎和血栓性微血管病导致的急性肾衰竭（ARF）。某些原发性肾小球疾病，包括免疫球蛋白（Ig）M肾病以及局灶节段性和弥漫性肾小球硬化，在一些热带国家较为普遍。毒蛇咬伤的肾脏并发症在热带地区也很常见。本文讨论并总结了文献中关于热带地区人类和实验动物模型肾脏疾病的临床综合征、病理特征及发病机制的重要研究成果。
