Overview of tropical nephrology.

Tropical nephrology covers renal diseases commonly seen in the tropics and elsewhere and specific tropical renal diseases seen mostly or only in the tropical area. Emphasis in this article is placed on the latter category, which includes renal involvement in tropical infectious diseases, natural toxin poisoning, and environmental renal problems. Pathologically, all renal structures can be affected. There is, therefore, a broad spectrum of pathologic changes, and clinical renal manifestations vary from mild urinary sediment changes to acute renal failure. Inflammatory processes plays an essential role in the pathogenesis of renal involvement in infection and toxin groups. Both models share the same inflammatory pathways through cytokines, chemokines, and mediators. Hemodynamic alterations, immune response, and direct nephrotoxicity are involved in the development of renal lesions.