Sitprija Visith
Queen Saovabha Memorial Institute, Bangkok, Thailand.
Semin Nephrol. 2003 Jan;23(1):3-11. doi: 10.1053/snep.2003.50000.
Tropical nephrology covers renal diseases commonly seen in the tropics and elsewhere and specific tropical renal diseases seen mostly or only in the tropical area. Emphasis in this article is placed on the latter category, which includes renal involvement in tropical infectious diseases, natural toxin poisoning, and environmental renal problems. Pathologically, all renal structures can be affected. There is, therefore, a broad spectrum of pathologic changes, and clinical renal manifestations vary from mild urinary sediment changes to acute renal failure. Inflammatory processes plays an essential role in the pathogenesis of renal involvement in infection and toxin groups. Both models share the same inflammatory pathways through cytokines, chemokines, and mediators. Hemodynamic alterations, immune response, and direct nephrotoxicity are involved in the development of renal lesions.
热带肾脏病学涵盖热带地区及其他地区常见的肾脏疾病，以及主要或仅见于热带地区的特定热带肾脏疾病。本文重点关注后一类疾病，其中包括热带传染病中的肾脏受累、天然毒素中毒以及环境性肾脏问题。在病理上，所有肾脏结构均可受累。因此，病理变化范围广泛，临床肾脏表现从轻微的尿沉渣改变到急性肾衰竭不等。炎症过程在感染和毒素类疾病导致肾脏受累的发病机制中起重要作用。这两类疾病通过细胞因子、趋化因子和介质共享相同的炎症途径。血流动力学改变、免疫反应和直接肾毒性均参与肾脏病变的发生发展。
