[阿苯达唑对小鼠旋毛虫包囊幼虫作用的形态学、组织学和组织化学观察]
[Morpholgical, histological and histochemical observations on the effect of albendazole on encysted larvae of Trichinella spiralis in mice].
作者信息
Chen X, Chen P, Ji F, Wang Y, Wang F, Wang F
机构信息
Department of Parasitology, Chengde Medical College, Chengde 067000.
出版信息
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999;17(3):152-4.
AIM
To study the mechanism of action of albendazole on encysted larvae of Trichinella spiralis in mice.
METHODS
Twelve Kunming strain mice each infected with 200 T. spiralis larvae were equally divided into two groups. Six mice of the treatment group were treated with 30 mg of albendazole/kg daily for 5 days. Morphological, histological and histochemical methods were used.
RESULTS
The encysted larvae of albendazole-treated group became significantly damaged, most worms were shrunken and surrounded by inflammatory cells. Histochemical study demonstrated that the glycogen and RNA content of the larvae in the treated group was decreased, the activities of SDH, ATPase, ACP were lower than those of the control group.
CONCLUSION
Albendazole can affect the physiological function of Trichinella spiralis.
目的
研究阿苯达唑对小鼠旋毛虫包囊幼虫的作用机制。
方法
将12只每只感染200条旋毛虫幼虫的昆明品系小鼠平均分为两组。治疗组6只小鼠每天按30mg阿苯达唑/千克给药，共给药5天。采用形态学、组织学和组织化学方法。
结果
阿苯达唑治疗组的包囊幼虫受到明显损伤，大多数虫体萎缩并被炎性细胞包围。组织化学研究表明，治疗组幼虫的糖原和RNA含量降低，SDH、ATP酶、ACP的活性低于对照组。
结论
阿苯达唑可影响旋毛虫的生理功能。
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