Siriyasatien Padet, Yingyourd Paisal, Nuchprayoon Surang
Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
J Med Assoc Thai. 2003 Jun;86 Suppl 2:S257-62.
Efficacy of albendazole against early and late stage of Trichinella spiralis infection in mice was determined. To determine the efficacy of albendazole against the early stage (enteral phase) of trichinosis, mice experimentally infected with T. spiralis were treated with albendazole 20 mg/kg at 7 days post infection for 15 days. Larvae were recovered from the infected mice 7 days after the treatment. The reduction rate of the larvae was 100 per cent. Efficacy of albendazole against the late stage (parenteral phase) of infection was determined at 30 days post infection. Mice were treated with albendazole at 20 mg/kg for 30 days. Larvae were recovered from the infected mice 7 days after the treatment. The reduction rate of the larvae was 71 per cent compared to the control group. In conclusion, albendazole was more effective in the early stage of infection than the late stage, the reduction was 100 per cent and 71 per cent with respect to the control group respectively.
测定了阿苯达唑对小鼠旋毛虫感染早期和晚期的疗效。为了确定阿苯达唑对旋毛虫病早期（肠内期）的疗效，将实验感染旋毛虫的小鼠在感染后7天用20毫克/千克阿苯达唑治疗15天。治疗7天后从感染小鼠中回收幼虫。幼虫减少率为100%。在感染后30天测定阿苯达唑对感染晚期（肠外期）的疗效。小鼠用20毫克/千克阿苯达唑治疗30天。治疗7天后从感染小鼠中回收幼虫。与对照组相比，幼虫减少率为71%。总之，阿苯达唑在感染早期比晚期更有效，相对于对照组，减少率分别为100%和71%。
