Gao P F, Chen W X, Xiao L Y, Yan X J
Department of Otolaryngology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Aug;14(8):347-8.
To investigate the existance of Epstein-Barr virus (EBV) and papilloma virus(HPV) in sinonasal malignant neoplasms.
EBV and HPV (including HPV6,11,16,18,33) gene were detected in paraffin-embedded tissues with polymerase chain reaction(PCR) from 32 cases of sinonasal malignant neoplasms.
EBV was detected in 12(37.5%), HPV in 21(65.6%); The coinfection of EBV and HPV was found in 6 cases with stage III-IV by TNM; 10 cases of nasal polyps contained neither EBV nor HPV.
Like HPV, there may be relationship between EBV and sinonasal malignant neoplasms. The coinfection of EBV and HPV is related to stage III-IV by TNM of sinonasal malignant neoplasms.
探讨鼻窦恶性肿瘤中EB病毒（EBV）和乳头瘤病毒（HPV）的存在情况。
采用聚合酶链反应（PCR）检测32例鼻窦恶性肿瘤石蜡包埋组织中的EBV和HPV（包括HPV6、11、16、18、33）基因。
EBV检测阳性12例（37.5%），HPV检测阳性21例（65.6%）；TNM分期为Ⅲ-Ⅳ期的病例中6例存在EBV和HPV合并感染；10例鼻息肉组织中EBV和HPV均未检出。
与HPV一样，EBV与鼻窦恶性肿瘤可能存在关联。EBV和HPV合并感染与鼻窦恶性肿瘤的TNM分期Ⅲ-Ⅳ期有关。
