Zhou M, Zhou W G, Yin H L
Department of Otorhinolaryngology, General Hospital of Nanjing Command, PLA, Nanjing 210002.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Dec;14(12):536-7.
To realize the relationship between IgA nephropathy (IgA-N) and immunological abnormality of tonsillae.
Thirty-one patients were diagnosed as IgA-N via renal puncture. Sixteen patients suffering from chronic tonsillitis as control. All resected tonsillae were labelled immunohistologically by ABC method.
The differences of expression of IgA, IgG in the tonsillae between above two groups were significantly obvious. The number of lymphocytes which can produce IgA increased in IgA-N tonsillae.
The immune functions are abnormal in IgA-N patients. Tonsillectomy can prevent the antigen invasion, eliminate IgA originated from tonsillae, decrease the IgA immunocomplex in circulation, therefore decrease the IgA immunocomplex deposition in the basal membrane of glomeruli.
了解IgA肾病（IgA-N）与扁桃体免疫异常之间的关系。
31例患者经肾穿刺诊断为IgA-N。16例慢性扁桃体炎患者作为对照。所有切除的扁桃体采用ABC法进行免疫组织学标记。
上述两组扁桃体中IgA、IgG表达差异显著。IgA-N扁桃体中产生IgA的淋巴细胞数量增加。
IgA-N患者免疫功能异常。扁桃体切除术可防止抗原侵入，消除源自扁桃体的IgA，减少循环中的IgA免疫复合物，从而减少IgA免疫复合物在肾小球基底膜的沉积。
