Kusakari C, Takasaka T
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Acta Otolaryngol Suppl. 1993;508:19-22. doi: 10.3109/00016489309130261.
IgA nephropathy (IgAN) is thought to be mediated by the glomerular deposition of circulating immune complexes containing IgA as the major antibody component. Tonsillitis often precedes IgAN, and tonsillectomy is an efficient treatment of IgAN. Thus, the tonsil may cause initial and/or progressive events leading to IgAN. To determine the pathological features of tonsillar lymphoid cells, we transferred tonsillar mononuclear cells from IgAN patients to SCID mice. Although human IgG-, IgM- and IgA-positive cells were detected in the spleens of SCID-Hu mice, they failed to reproduce the increase in serum IgA level and glomerular deposition. These results suggest that other factors are needed for the progression of IgAN.
IgA肾病（IgAN）被认为是由以IgA作为主要抗体成分的循环免疫复合物在肾小球沉积介导的。扁桃体炎常先于IgAN出现，扁桃体切除术是IgAN的一种有效治疗方法。因此，扁桃体可能引发导致IgAN的初始和/或进展性事件。为了确定扁桃体淋巴样细胞的病理特征，我们将IgAN患者的扁桃体单个核细胞移植到SCID小鼠体内。尽管在SCID-Hu小鼠的脾脏中检测到了人IgG、IgM和IgA阳性细胞，但它们未能重现血清IgA水平升高和肾小球沉积的情况。这些结果表明，IgAN的进展还需要其他因素。
