McCulley Timothy J, Luu James K, Marmor Michael F, Feuer William J
The University of California, Irvine, Department of Ophthalmology, Irvine, Calif 92697-4375, USA.
Ophthalmologica. 2002 Nov-Dec;216(6):455-8. doi: 10.1159/000067549.
This study evaluates the effect of sildenafil on choroidal vascular congestion and its correlation with visual effects. Thirteen healthy subjects were randomized to a sildenafil group (n = 7, 3 M, 4 F), who received 200 mg of sildenafil, and a control (n = 6, 5 F, 1 M) group, who received no drug. Measurements of choroidal thickness with ultrasonography, color vision with Desaturated Panel D-15 Test, and contrast sensitivity with CSV-1000e charts (Vector Vision) were performed at baseline and at 90 and 180 min. Mean choroidal thickness and contrast sensitivity did not change significantly relative to baseline in either group. However, the variance in differences between repeat and baseline measurements of choroidal thickness was significantly higher at 90 min (p = 0.003) in the sildenafil subjects. Color discrimination error scores increased after sildenafil but did not correlate with changes in choroidal thickness. An oral dose of 200 mg of sildenafil caused small inconsistent changes in choroidal thickness, which did not correlate with visual effects.
本研究评估西地那非对脉络膜血管充血的影响及其与视觉效果的相关性。13名健康受试者被随机分为西地那非组（n = 7，3名男性，4名女性），接受200毫克西地那非，以及对照组（n = 6，5名女性，1名男性），不接受任何药物。在基线、90分钟和180分钟时，用超声测量脉络膜厚度，用去饱和D-15色盘测试测量色觉，用CSV-1000e图表（Vector Vision）测量对比敏感度。两组的平均脉络膜厚度和对比敏感度相对于基线均无显著变化。然而，西地那非组在90分钟时脉络膜厚度重复测量与基线测量之间差异的方差显著更高（p = 0.003）。服用西地那非后颜色辨别误差评分增加，但与脉络膜厚度变化无关。口服200毫克西地那非会引起脉络膜厚度的微小且不一致的变化，且与视觉效果无关。
