通过MIB1检测中耳胆脂瘤上皮增殖的侵袭性及定量分析
Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1.
作者信息
Mallet Y, Nouwen J, Lecomte-Houcke M, Desaulty A
机构信息
Departments of Otorhinolaryngology, Centre Hospitalier Universitaire Lille, Lille, France. y-mallet@o-lambret
出版信息
Laryngoscope. 2003 Feb;113(2):328-31. doi: 10.1097/00005537-200302000-00024.
OBJECTIVE
To assess an easy method that predicts cholesteatoma aggressiveness.
STUDY DESIGN
An experimental prospective study.
METHODS
Monoclonal antibody MIB1 was used to determine epithelium proliferation in 91 cholesteatomatous ears. Clinical and surgical parameters were compared with proliferation activity to determine pathological and clinical correlation.
RESULTS
Statistical correlations were established between hyperproliferation of the cholesteatoma and severe bone erosion (leading to major cholesteatoma complications) and between hyperproliferation and middle ear inflammation (associated with more surgical difficulties and a higher risk of recurrence). A high proliferation index was also found in children's cholesteatoma, which is known to have more aggressive behavior.
CONCLUSION
Immunohistochemical use of the MIB1 antibody is a simple technique that can help to determine the aggressiveness of a cholesteatoma.
目的
评估一种预测胆脂瘤侵袭性的简易方法。
研究设计
一项实验性前瞻性研究。
方法
采用单克隆抗体MIB1测定91例胆脂瘤耳的上皮增殖情况。将临床和手术参数与增殖活性进行比较，以确定病理与临床的相关性。
结果
胆脂瘤的过度增殖与严重骨质侵蚀（导致主要的胆脂瘤并发症）之间以及过度增殖与中耳炎症（与更多手术困难和更高复发风险相关）之间建立了统计学相关性。在儿童胆脂瘤中也发现了高增殖指数，已知儿童胆脂瘤具有更具侵袭性的行为。
结论
MIB1抗体的免疫组织化学应用是一种简单的技术，可有助于确定胆脂瘤的侵袭性。
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