Dai Jian-rong, Zhou Xiao-nong, Liang You-sheng, Zhang Yan-ping, Jiang Yu-ji, Xi Wei-ping, Huang Yi-xin, Chen Chang, Huang Ming-xi, Zhu Yin-chang
Jiangsu Institute of Parasitic Diseases, Wuxi 214064.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20(2):101-5.
To understand the variation in response of Oncomelania hupensis to niclosamide.
Snails were collected from 37 sampling areas distributed in 10 provinces (municipalities) using random environmental sampling methods in accordance with the different types and categories of snail habitats. In laboratory the snails were immersed in solutions of niclosamide for 24 and 48 hours at 25 degrees C.
1.0 mg/L niclosamide showed 100% killing effect on snails in 24 hours. The LC50 concentrations for snails immersed for 24 hours ranged from 0.0320 to 0.1689 mg/L with a mean value of 0.0920 mg/L. 0.5 mg/L niclosamide showed 100% killing effect on snails in 48 hours. The LC50 values for snails immersed for 48 hours ranged between 0.0299 and 0.1114 mg/L with a mean of 0.0627 mg/L. There is a significant difference in snail sensitivity to niclosamide between sampling areas.
The sensitivity to niclosamide varied in snails from different sampling fields, but the chemical in a concentration of 1.0 mg/L showed 100% effect of killing snails, which is consistent to the manual of schistosomiasis control.
了解湖北钉螺对氯硝柳胺的反应变化。
按照钉螺栖息地的不同类型和类别，采用随机环境抽样方法，从分布于10个省（直辖市）的37个采样区域采集钉螺。在实验室中，将钉螺于25℃下浸泡在氯硝柳胺溶液中24小时和48小时。
1.0mg/L氯硝柳胺在24小时内对钉螺显示出100%的杀灭效果。浸泡24小时的钉螺的LC50浓度范围为0.0320至0.1689mg/L，平均值为0.0920mg/L。0.5mg/L氯硝柳胺在48小时内对钉螺显示出100%的杀灭效果。浸泡48小时的钉螺的LC50值在0.0299至0.1114mg/L之间，平均值为0.0627mg/L。不同采样区域的钉螺对氯硝柳胺的敏感性存在显著差异。
不同采样区域的钉螺对氯硝柳胺的敏感性有所不同，但1.0mg/L浓度的该化学物质显示出100%的杀螺效果，这与血吸虫病防治手册一致。
