双氢青蒿素联合磷酸萘酚喹治疗恶性疟患者的疗效
[Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria].
作者信息
Wang Shan-qing, Meng Feng, Shen Heng, Wen Yan, Zhuo Kai-ren, Zhu Qi-xian, Pang Xue-jian, Lin Shi-gan, Zeng Lin-hai
机构信息
Hainan Provincial Institute of Tropical Diseases, Haikou 570203.
出版信息
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20(3):180-2.
OBJECTIVE
To observe the therapeutic efficacy of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria.
METHODS
Patients with Plasmodium falciparum were selected as the subjects, treated with a single dose of dihydroarteminisinin 160 mg combined with naphthoquine phosphate 400 mg (for adults) and followed up in preselective time by blood and temperature examination for 28 days after drug administration.
RESULTS
37 patients with falciparum malaria were treated and followed up. One patient had recrudescence and the cure rate in 28 days was 97.3%(36/37). The mean fever clearance time was (15.8 +/- 8.7) hours; the mean parasite clearance time was (27.6 +/- 13.2) hours; the mean reduction parasite rate in 24 hours was 96.7% +/- 26.5%. No apparent side effect was observed.
CONCLUSION
A combination of dihydroartemisinin and naphthoquine is effective for the treatment of patients with falciparum malaria.
目的
观察双氢青蒿素联合磷酸萘酚喹治疗恶性疟的疗效。
方法
选取恶性疟患者为研究对象，采用单剂量双氢青蒿素160mg联合磷酸萘酚喹400mg（成人剂量）进行治疗，给药后按预定时间进行血检和体温检测，随访28天。
结果
共治疗并随访37例恶性疟患者。1例患者复发，28天治愈率为97.3%（36/37）。平均退热时间为（15.8±8.7）小时；平均原虫清除时间为（27.6±13.2）小时；24小时平均原虫减少率为96.7%±26.5%。未观察到明显副作用。
结论
双氢青蒿素与萘酚喹联合应用治疗恶性疟患者有效。
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