Li G Q, Wang X H, Guo X B, Fu L C, Jian H X, Chen P Q, Li G Q
Tropical Medicine Institute, Guangzhou University of Traditional Chinese Medicine, PR China.
Southeast Asian J Trop Med Public Health. 1999 Mar;30(1):17-9.
Forty patients with uncomplicated P. falciparum malaria were respectively treated in an open randomized comparative study of dihydroartemisinin tablets given at total doses of 480 mg over 5 days and 640 mg over 7 days in a drug-resistant malaria endemic area in Hainan, China. The result showed that all patients were clinically cured. In 5-day and 7-day groups, the mean fever clearance times (FCT) were 26.1+/-10.2 and 21.1+/-11.8 hours respectively; the mean parasite clearance times (PCT) were 58.7+/-20.9 and 59.4+/-20.9 hours respectively, which showed no significant difference. 28-day follow-ups were accomplished on 39 and 37 cases respectively in two groups, the recrudescence rates were 20.5% (8/39) in 5-day group, while 2.7% (1/37) in 7-day group with significant difference (chi2=4.19, p<0.05). No clinical drug-related side effect was found in two groups during treatment.
在中国海南一个疟疾耐药流行地区，对40例无并发症的恶性疟患者进行了一项开放随机对照研究，分别给予总剂量480毫克、疗程5天的双氢青蒿素片和总剂量640毫克、疗程7天的双氢青蒿素片。结果显示所有患者均临床治愈。5天疗程组和7天疗程组的平均退热时间（FCT）分别为26.1±10.2小时和21.1±11.8小时；平均疟原虫清除时间（PCT）分别为58.7±20.9小时和59.4±20.9小时，差异无统计学意义。两组分别对39例和37例患者进行了28天随访，5天疗程组复发率为20.5%（8/39），7天疗程组为2.7%（1/37），差异有统计学意义（χ2=4.19，p<0.05）。治疗期间两组均未发现与药物相关的临床副作用。
