Qiu Daoming, Kao Peter N
Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California 94305, USA.
Drugs R D. 2003;4(1):1-18. doi: 10.2165/00126839-200304010-00001.
Extracts of Tripterygium wilfordii hook. f. (leigong teng, Thundergod vine) are effective in traditional Chinese medicine for treatment of immune inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, nephritis and asthma. Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro. Triptolide inhibits lymphocyte activation and T-cell expression of interleukin-2 at the level of transcription. In all cell types examined, triptolide inhibits nuclear factor-kappaB transcriptional activation at a unique step in the nucleus after binding to DNA. Further characterisation of the molecular mechanisms of triptolide action will serve to elucidate pathways of immune system regulation.
雷公藤（Tripterygium wilfordii hook. f.）提取物在传统中药中对治疗包括类风湿性关节炎、系统性红斑狼疮、肾炎和哮喘在内的免疫炎症性疾病有效。对雷公藤提取物中存在的萜类化合物进行表征后发现，二萜三环氧化物雷公藤内酯醇是体外观察到的大部分免疫抑制、抗炎和抗增殖作用的原因。雷公藤内酯醇在转录水平上抑制淋巴细胞活化和白细胞介素-2的T细胞表达。在所有检测的细胞类型中，雷公藤内酯醇在与DNA结合后于细胞核内的一个独特步骤抑制核因子-κB转录激活。对雷公藤内酯醇作用分子机制的进一步表征将有助于阐明免疫系统调节途径。
