雷公藤红素：结构修饰、构效关系、生物活性、临床开发及作用机制。
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
机构信息
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, P.R. China.
出版信息
Nat Prod Rep. 2012 Apr;29(4):457-75. doi: 10.1039/c2np00088a. Epub 2012 Jan 23.
Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
雷公藤红素，是卫矛科雷公藤属植物雷公藤的主要活性成分，因其独特的二萜三环氧结构和多种生物活性而受到广泛关注。本文主要综述了雷公藤红素在过去四十年中的结构修饰、构效关系、药理学和临床开发研究进展。
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