Goodman N, Hughes J F
Bioelectrostatics Research Centre, Department of Electronics and Computer Science, University of Southampton, Southampton, UK.
Clin Exp Allergy. 2002 Nov;32(11):1613-9. doi: 10.1046/j.1365-2222.2002.01525.x.
To reduce the risk of sensitization and the elicitation of allergy symptoms, it is important to reduce the level of allergens in the home. It has previously been demonstrated that corona discharge, the process by which ionizers produce ions, can destroy the major house dust mite allergen Der p 1.
In this paper the denaturing efficacy of an experimental ionizer and two commercially available products are evaluated.
The first test was conducted in an electrically grounded chamber with samples of Der p 1 placed in various positions for 1, 2 and 3 weeks. The second test was conducted in situ in an unoccupied, furnished office room for 1 week. Der p 1 concentration was quantified by two-site monoclonal antibody enzyme-linked immunosorbent assay (ELISA).
All ionizers in both tests caused significant reductions in allergen concentration (P < 0.05), reaching a maximum of 92% with the experimental ionizer in the chamber after 3 weeks. The percentage reductions observed in situ with the experimental and the larger commercial ionizer were similar, reaching a maximum of 32% at a distance of 4 m away from the experimental ionizer after 1 week of exposure.
With a revised protocol for use, air ionizers may offer a simple, efficient and inexpensive way to reduce allergen levels in the domestic environment.
为降低致敏风险和诱发过敏症状，降低家庭中的过敏原水平至关重要。此前已证明，电晕放电（离子发生器产生离子的过程）可破坏主要的屋尘螨过敏原Der p 1。
本文评估了一种实验性离子发生器和两种市售产品的变性效果。
第一次测试在接地室内进行，将Der p 1样本放置在不同位置1、2和3周。第二次测试在一间无人居住、配备家具的办公室内原位进行1周。通过双位点单克隆抗体酶联免疫吸附测定（ELISA）对Der p 1浓度进行定量。
两次测试中所有离子发生器均使过敏原浓度显著降低（P < 0.05），在室内使用实验性离子发生器3周后，降低幅度最大达92%。实验性离子发生器和较大型市售离子发生器在原位观察到的降低百分比相似，暴露1周后，在距实验性离子发生器4 m处降低幅度最大达32%。
通过修订使用方案，空气离子发生器可能提供一种简单、高效且廉价的方法来降低家庭环境中的过敏原水平。
