Arbes Samuel J, Cohn Richard D, Yin Ming, Muilenberg Michael L, Burge Harriet A, Friedman Warren, Zeldin Darryl C
Division of Intramural Research, National Institute of Environmental Health Sciences/NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA.
J Allergy Clin Immunol. 2003 Feb;111(2):408-14. doi: 10.1067/mai.2003.16.
Although exposure to house dust mite allergen is a major risk factor for allergic sensitization and asthma, nationwide estimates of dust mite allergen levels in US homes have not been reported.
The purpose of this study was to estimate the prevalence of dust mite allergen in beds of US homes and to identify predictors of dust mite allergen concentration.
Data were obtained from the first National Survey of Lead and Allergens in Housing, a cross-sectional survey of 831 permanently occupied noninstitutional housing units that permitted resident children. Dust mite allergen concentration (Der f 1 plus Der p 1) was determined from a dust sample collected from a bed. The percentages of homes with concentrations at or greater than detection, 2.0 microg/g bed dust, and 10.0 microg/g bed dust were estimated. Independent predictors of allergen concentration were assessed with multivariable linear regression.
The percentages of US homes with dust mite allergen concentrations at or greater than detection, 2.0 microg/g, and 10.0 microg/g were 84.2% (SE, 1.73), 46.2% (SE, 2.0), and 24.2% (SE, 2.1), respectively. Independent predictors of higher levels were older homes, non-West census regions, single-family homes, no resident children, lower household income, heating sources other than forced air, musty or mildew odor, and higher bedroom humidity.
Most US homes have detectable levels of dust mite allergen in a bed. Levels previously associated with allergic sensitization and asthma are common in US bedrooms. Predictors can be used to identify conditions under which homes are more likely to have increased dust mite allergen levels.
尽管接触屋尘螨过敏原是过敏性致敏和哮喘的主要危险因素,但美国国内屋尘螨过敏原水平的全国性估计尚未见报道。
本研究旨在估计美国家庭床褥中屋尘螨过敏原的流行情况,并确定屋尘螨过敏原浓度的预测因素。
数据来自首次全国住房铅与过敏原调查,这是一项对831个允许有常住儿童的永久性非机构住房单元进行的横断面调查。从床褥上采集的灰尘样本中测定屋尘螨过敏原浓度(Der f 1加Der p 1)。估计了浓度达到或高于检测水平、2.0微克/克床尘和10.0微克/克床尘的家庭百分比。通过多变量线性回归评估过敏原浓度的独立预测因素。
美国家庭中屋尘螨过敏原浓度达到或高于检测水平、2.0微克/克和10.0微克/克的家庭百分比分别为84.2%(标准误,1.73)、46.2%(标准误,2.0)和24.2%(标准误,2.1)。较高水平的独立预测因素包括年代较久的房屋、非西部人口普查地区、独栋房屋、无常住儿童、家庭收入较低、非强制通风的供暖源、有霉味或发霉气味以及卧室湿度较高。
大多数美国家庭床褥中可检测到屋尘螨过敏原。以前与过敏性致敏和哮喘相关的水平在美国卧室中很常见。预测因素可用于识别家庭中屋尘螨过敏原水平更可能升高的情况。