Li Q, Chou G, Dou C, Wang Z, Huang F
China Pharmaceutical University, Nanjing 210038.
Zhong Yao Cai. 1997 Dec;20(12):629-31.
Both of aqueous extract and alconol extract of Radix Linderae at a dose 5 g/kg and 10 g/kg could length obviously pain threshold in mice in hot plate test. The samples at a dose 20 g/kg could inhibit significantly the writhing frequency induced by potassium antimony tartate in mice, also antagonize the swelling of ear induced by inflammatory agent and decrease the swelling rate. The component further isolated from the plant could antagonize the swelling of rat toes induced by carrageenin.
乌药水提取物和醇提取物在剂量为5g/kg和10g/kg时,均可明显延长热板法所致小鼠的痛阈。剂量为20g/kg时,可显著抑制酒石酸锑钾所致小鼠扭体反应的次数,还可对抗炎症介质所致小鼠耳肿胀,并降低肿胀率。从该植物中进一步分离得到的成分可对抗角叉菜胶所致大鼠足趾肿胀。