Cao B J, Meng Q Y, Ji N
Department of Pharmacology, Hunan Institute of Pharmaceutical Industry, Changsha, People's Republic of China.
Planta Med. 1992 Dec;58(6):496-8. doi: 10.1055/s-2006-961534.
The analgesic and anti-inflammatory effects of Ranunculus japonicus extract after parenteral administration were determined in several animal models. The extract inhibited the mice writhing responses caused by acetic acid and raised the pain thresholds of mice in the hot-plate test. The extract also inhibited the paw edema of rats induced by carrageenin, ear swelling of mice caused by xylene, mice vascular permeability increase induced by acetic acid, and granuloma formation in rats.
通过几种动物模型测定了毛茛提取物经肠胃外给药后的镇痛和抗炎作用。该提取物抑制了由乙酸引起的小鼠扭体反应，并提高了热板试验中小鼠的痛阈。该提取物还抑制了角叉菜胶诱导的大鼠足爪水肿、二甲苯引起的小鼠耳肿胀、乙酸诱导的小鼠血管通透性增加以及大鼠肉芽肿形成。
