Liu X, Fang K, Pan J, Wang Y
Nanjing University of TCM, 210029.
Zhong Yao Cai. 2000 Jul;23(7):388-9.
Using 4(3)-quinazolinedione, the active constituent of "Daqingye", as the quality control criteria, 4 samples of the herbal drug collected from Isatis indigotica, Baphicacanthus cusia, Polygonum tinctorium and Clerodendron cyrtophyllum were comparetively analyzed by RP-HPLC. The results showed that the average 4(3)-quinazolinedione contents (microgram/g) were 30.7, 7.2, 4.4 and 27.5 respectively. This method was proved to be quick, simple and reproducible, and provided a reliable basis for the quality control and evaluation of Chinese Traditional Drug "Daqingye".
以“大青叶”的有效成分4(3)-喹唑啉二酮为质量控制标准，采用反相高效液相色谱法（RP-HPLC）对采集自菘蓝、马蓝、蓼蓝和路边青的4种大青叶药材样品进行了比较分析。结果表明，4(3)-喹唑啉二酮的平均含量（微克/克）分别为30.7、7.2、4.4和27.5。该方法快速、简便、重现性好，为中药“大青叶”的质量控制和评价提供了可靠依据。
