Zheng L M, Liu X L, Xia Z Y
Shenzhen Municipal Central Hospital, Guangdong 518036.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Mar;21(3):177-9.
To observe the gastrointestinal protective effect of Composite Salviae Injection (CSI) in patients undergoing cardio-pulmonary bypass (CPB) heart surgery.
Eighteen patients, who were scheduled to cardiac surgery (either atrial or ventrical septal repairing) undergoing CPB were randomized equally into two groups. Before CPB, the CSI group was treated with CSI 0.5 ml/kg by intravenous dripping and the control group was treated with normal saline in equal volume. The intragastric mucosa pH value (pHi) of patients was monitored by tensiometer.
As compared with the pre-CPB value, pHi lowered significantly during, 1 h and 2 hrs after CPB in the control group (P < 0.05 or P < 0.01), while in the CSI group, pHi lowered significantly only during CPB (P < 0.05), but with insignificant change at 1 h and 2 hrs after CPB. Comparison between the two groups showed that pHi value in the CSI group was higher significantly than that in the control group at all respective monitoring period (P < 0.05).
CSI has gastrointestinal protective effect in patients undergoing CPB cardiosurgery to some extent.
观察复方丹参注射液（CSI）对体外循环（CPB）心脏手术患者胃肠道的保护作用。
18例计划行CPB心脏手术（房间隔或室间隔修补）的患者被随机均分为两组。CPB前，CSI组静脉滴注CSI 0.5 ml/kg，对照组静脉滴注等体积生理盐水。采用张力计监测患者胃黏膜pH值（pHi）。
与CPB前相比，对照组CPB期间、CPB后1小时和2小时pHi显著降低（P < 0.05或P < 0.01），而CSI组仅在CPB期间pHi显著降低（P < 0.05），CPB后1小时和2小时变化不显著。两组比较显示，各监测时段CSI组的pHi值均显著高于对照组（P < 0.05）。
复方丹参注射液对CPB心脏手术患者胃肠道有一定保护作用。
