Fine Samson W, Li Maomi
Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 E210th St, North 4 Silver Zone, Bronx, NY 10467, USA.
Am J Clin Pathol. 2003 Feb;119(2):259-64. doi: 10.1309/GRH4-JWX6-J9J7-QQTA.
Granular cell tumors (GCTs) typically express S-100 protein, which has been used as a marker in differential diagnosis. Calretinin, a calcium-binding protein related structurally to S-100, and inhibin, a polypeptide hormone secreted primarily by ovarian granulosa cells and testicular Sertoli cells and functioning as an inhibitor for pituitary follicle-stimulating hormone secretion, are potentially useful but not well-evaluated markers for GCTs. We studied 43 cases of GCT with antibodies to calretinin, the inhibin alpha-subunit, and S-100 protein. All tumors were positive for inhibin alpha-subunit and S-100 protein, with 50% or more cells showing moderate to strong staining. Forty tumors (93%) were positive for calretinin, ranging from focal weak to diffuse strong staining. Enhanced staining for calretinin in the tumor cells adjacent to hyperplastic squamous epithelium was observed in 9 of 13 cases showing pseudoepitheliomatous hyperplasia. Calretinin and the inhibin alpha-subunit are useful markers for GCTs. The expression of calretinin, a primarily neuronal protein, in GCTs further supports its neural differentiation or derivation. The elevated calretinin expression in the tumor cells adjacent to the hyperplastic squamous epithelium suggests a role for calretinin in the tumor cells-squamous epithelium interaction.
颗粒细胞瘤（GCTs）通常表达S-100蛋白，该蛋白已被用作鉴别诊断的标志物。钙结合蛋白钙视网膜蛋白在结构上与S-100相关，抑制素是一种主要由卵巢颗粒细胞和睾丸支持细胞分泌的多肽激素，其功能是抑制垂体促卵泡激素的分泌，它们是GCTs潜在有用但尚未得到充分评估的标志物。我们用抗钙视网膜蛋白、抑制素α亚基和S-100蛋白的抗体研究了43例GCT。所有肿瘤的抑制素α亚基和S-100蛋白均呈阳性，50%或更多的细胞呈中度至强染色。40例肿瘤（93%）钙视网膜蛋白呈阳性，染色范围从局灶性弱阳性到弥漫性强阳性。在13例显示假上皮瘤样增生的病例中，有9例观察到增生性鳞状上皮相邻的肿瘤细胞中钙视网膜蛋白染色增强。钙视网膜蛋白和抑制素α亚基是GCTs的有用标志物。钙视网膜蛋白是一种主要的神经元蛋白，在GCTs中的表达进一步支持了其神经分化或起源。增生性鳞状上皮相邻的肿瘤细胞中钙视网膜蛋白表达升高表明钙视网膜蛋白在肿瘤细胞与鳞状上皮的相互作用中发挥作用。
