异硒脲盐在体内的分布与行为。VI. 硒衍生物的分布与辐射防护的比较研究。
Distribution and behavior of isoselenouronium salts in the body. VI. Comparative study of distribution and radioprotectivity of selenium derivatives.
作者信息
Kozák I, Kronrád L, Dienstbier Z
出版信息
Strahlentherapie. 1976 Jan;151(1):84-7.
PMID:1258079
Abstract
The protective effect of AESe, 2-ASe, and Se-MEG during irradiation with a dose rate of 500 R/min was followed. The protective effect of 2-ASe is substantially lower during the dose rate of 20 R/min and even during an increased dose. AESe and Se-MEG are noneffective. The time of duration of the protective effect of 2-ASe corresponds to the period of its high concentration in the organism after the administration, i.e. ca. 45 min.
摘要
对亚硒酸金（AESe）、2-氨基乙硒酸（2-ASe）和硒蛋氨酸（Se-MEG）在剂量率为500伦琴/分钟的辐照过程中的保护作用进行了跟踪研究。在剂量率为20伦琴/分钟时，甚至在剂量增加时，2-ASe的保护作用都显著降低。亚硒酸金和硒蛋氨酸无效。2-ASe保护作用的持续时间与给药后其在生物体内高浓度的时期相对应，即约45分钟。
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