Păuşescu E, Păun C, Olinescu R, Teodosiu T
Strahlentherapie. 1976 Jan;151(1):88-95.
The changes in the amounts of blood and tissular sulfhydryl groups and lipid peroxides were investigated in lethally gamma-irradiated rats treated with cystamine, AET (radioprotectors) or alpha-methyl-dopa (a radiosensitizer). The results of experiments revealed the following findings: 1. The ionizing radiation generally causes increases in the levels of tissular sulfhydryl groups and lipid peroxides (excepting the hepatic levels of these compounds). 2. AET and, especially, cystamine are able to reverse the radiation-induced changes in the tissular amounts of sulfhydryl groups and lipid peroxides; there are close relationships between this effect (including its intensity and extension) and the radioprotective action of these drugs. 3. In spite of its radiosensitizing action, alpha-methyl-dopa induces approximately similar changes in the tissular amounts of sulfhydryl groups and lipid peroxides, suggesting that biochemical processes other than an excessive yield of free radicals are also involved in radiosensitivity.
研究了用半胱胺、AET（辐射防护剂）或α-甲基多巴（辐射增敏剂）处理的经致死剂量γ射线照射的大鼠血液和组织中巯基及脂质过氧化物含量的变化。实验结果显示了以下发现：1. 电离辐射通常会导致组织中巯基和脂质过氧化物水平升高（肝脏中这些化合物的水平除外）。2. AET，尤其是半胱胺，能够逆转辐射引起的组织中巯基和脂质过氧化物含量的变化；这种作用（包括其强度和范围）与这些药物的辐射防护作用之间存在密切关系。3. 尽管α-甲基多巴具有辐射增敏作用，但它在组织中巯基和脂质过氧化物含量上诱导出大致相似的变化，这表明除自由基过量产生之外的生化过程也参与了辐射敏感性。
