Linneberg A, Nielsen N H, Madsen F, Frølund L, Dirksen A, Jørgensen T
Centre for Preventive Medicine, Glostrup University Hospital, Denmark.
Allergy. 2003 Jan;58(1):21-6. doi: 10.1034/j.1398-9995.2003.23639.x.
The aim of the study was to investigate the association between exposure to cat and dog in the home and the development (incidence) of IgE sensitization to cat and dog.
Participants in a population-based study of 15-69-year-olds in 1990 were invited to a follow-up in 1998. Serum IgE antibodies against common inhalant allergens was assessed in 734 subjects (participation rate 69.0%) on two occasions 8 years apart. Information about current or previous keeping of cats and dogs in the home was obtained in a questionnaire at baseline.
A cat in the home currently was significantly associated with the development of IgE sentisization to cat (adjusted odds ratio 8.4, 95% confidence interval (CI) 1.7-42.7). Moreover, an atopic predisposition in terms of IgE sensitization to allergens other than cat at baseline was an independent risk factor for the development of IgE sensitization to cat. A dog in the home was not significantly associated with the development of IgE sensitization to dog.
In this adult population, exposure to a cat in the home increased the risk of developing IgE sensitization to cat. More prospective data are needed on this issue.
本研究旨在调查家中接触猫和狗与对猫和狗的IgE致敏反应的发生（发病率）之间的关联。
1990年对15 - 69岁人群进行的一项基于人群的研究中的参与者被邀请在1998年进行随访。在734名受试者（参与率69.0%）中，相隔8年对常见吸入性过敏原的血清IgE抗体进行了两次评估。在基线时通过问卷调查获取有关家中当前或以前养猫和狗的信息。
家中当前养猫与对猫的IgE致敏反应的发生显著相关（调整后的优势比为8.4，95%置信区间（CI）为1.7 - 42.7）。此外，基线时对猫以外的过敏原的IgE致敏反应方面的特应性易感性是对猫的IgE致敏反应发生的独立危险因素。家中养狗与对狗的IgE致敏反应发生无显著关联。
在这一成年人群中，家中接触猫会增加对猫发生IgE致敏反应的风险。关于这个问题需要更多的前瞻性数据。
