Liccardi G, Mazzarello M G, Senna G, Russo M, Barber D, Martin S, Caruso B, Perfumo M, Staffa C, Dente B, De Martino M, D'Amato G
Department of Chest Diseases, Division of Pneumology and Allergology, "A.Cardarelli" Hospital, Naples, Italy.
Eur Ann Allergy Clin Immunol. 2005 Mar;37(3):87-9.
The relationship between exposure to cat/dog in domestic environments and development of allergic sensitization to pet allergens is still controversial.
To test the role of indirect exposure to cat, we aimed to evaluate the amounts of cat specific IgE in sensitized subjects with or without cat at home.
Three hundred six adult patients with a previous diagnosis of allergic sensitization to cat allergens (by skin prick test) were enrolled for this study. Among 306 men and women sensitized to cat (and other allergens), 150 owned a cat for at least 10 years ( direct exposure) and 156 had never owned this animal (indirect exposure). An internal questionnaire specifically designed for the study was completed by the same allergists during the screening consultation: the results of skin prick tests, personal and clinical data, periods of symptoms and characteristics of cat ownership were carefully recorded. Specific IgE to cat extract was determined by the Pharmacia CAP System FEIA (Pharmacia Diagnostics, Uppsala, Sweden) and Immulite 2000 (Diagnostic Products Corporation, Los Angeles, USA) RESULTS: Although specific IgE to cat allergen were significantly higher in patients with cat at home (F = 42.77; p < 0.001), high amounts of these antibodies were found also in sera of subjects indirectly exposed to cats.
The results of our study demonstrate that the degree of serological sensitization to cat allergens may be relevant also in subjects without any direct contact with cats (indirect exposure).
家庭环境中接触猫/狗与对宠物过敏原的过敏致敏发展之间的关系仍存在争议。
为了测试间接接触猫的作用，我们旨在评估家中有无猫的致敏受试者体内猫特异性IgE的含量。
本研究纳入了306名先前诊断为对猫过敏原过敏致敏（通过皮肤点刺试验）的成年患者。在306名对猫（和其他过敏原）致敏的男性和女性中，150人拥有猫至少10年（直接接触），156人从未拥有过这种动物（间接接触）。在筛查咨询期间，由同一位过敏症专科医生完成一份专门为本研究设计的内部问卷：仔细记录皮肤点刺试验结果、个人和临床数据、症状发作期以及养猫的特征。采用Pharmacia CAP系统FEIA（瑞典乌普萨拉的Pharmacia Diagnostics公司）和Immulite 2000（美国洛杉矶的诊断产品公司）测定猫提取物特异性IgE。结果：虽然家中养猫的患者体内猫过敏原特异性IgE显著更高（F = 42.77；p < 0.001），但在间接接触猫的受试者血清中也发现了大量此类抗体。
我们的研究结果表明，对猫过敏原的血清致敏程度在未与猫有任何直接接触（间接接触）的受试者中也可能具有相关性。
