Vynodradova R P, Kicherenko M E, Efymets T I
Ukr Biokhim Zh. 1976 Jan-Feb;48(1):58-60.
The studies were performed in methionine, lysine and glycine aminoacylation of the total tRNA preparations isolated from the rat liver 3 h after total irradiation with X-rays with a dose of 800 R as well as after administration of nicotinic acid and proserine 4 h before decapitation of the animals. The tRNA preparations isolated from the irradiated animals liver are established to accept methionine, glycine and lysine to a less extent as compared with the normal state. The tRNA preparations isolated from the animal liver after administration of nicotinic acid accept methionine and glycine to a less degree and in the tRNA preparations from the liver of animals which were administered proserine the acceptance intensity lowers only with respect to lysine.
这些研究是在对大鼠肝脏进行800伦琴X射线全身照射3小时后,以及在动物断头前4小时给予烟酸和脯氨酸后,对从大鼠肝脏分离的总tRNA制剂进行甲硫氨酸、赖氨酸和甘氨酸氨酰化反应时进行的。已证实,与正常状态相比,从受辐照动物肝脏分离的tRNA制剂接受甲硫氨酸、甘氨酸和赖氨酸的程度较低。给予烟酸后从动物肝脏分离的tRNA制剂接受甲硫氨酸和甘氨酸的程度较低,而在给予脯氨酸的动物肝脏的tRNA制剂中,接受强度仅相对于赖氨酸降低。