α干扰素成功治疗肠道病毒引起的心肌炎。

Successful treatment of enterovirus-induced myocarditis with interferon-alpha.

作者信息

Daliento Luciano, Calabrese Fiorella, Tona Francesco, Caforio Alida L P, Tarsia Giandomenico, Angelini Annalisa, Thiene Gaetano

机构信息

Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy.

出版信息

J Heart Lung Transplant. 2003 Feb;22(2):214-7. doi: 10.1016/s1053-2498(02)00565-x.

DOI:10.1016/s1053-2498(02)00565-x

PMID:12581773

Abstract

No randomized, placebo-controlled studies have investigated interferon-alpha therapy in enterovirus-proven myocarditis. This report describes 2 patients with enterovirus-induced myocarditis (1 with associated Churg-Strauss syndrome) who at follow-up endomyocardial biopsy showed clinical and hemodynamic improvement and viral clearance (using polymerase chain reaction) after interferon-alpha therapy.

摘要

尚无随机、安慰剂对照研究对经肠道病毒证实的心肌炎进行干扰素-α治疗的研究。本报告描述了2例肠道病毒诱导的心肌炎患者（1例伴有Churg-Strauss综合征），在随访时进行心内膜心肌活检显示，干扰素-α治疗后临床和血流动力学得到改善，且病毒清除（采用聚合酶链反应）。