Beltran S, Douadi Y, Lescure F X, Hanau M, Laurans G, Ducroix J P
Infectiology and Internal Medicine Unit, Hôpital Nord, Place Victor Pauchet, 80054 Amiens, France.
Eur J Clin Microbiol Infect Dis. 2003 Jan;22(1):49-50. doi: 10.1007/s10096-002-0850-x. Epub 2003 Jan 18.
This case report highlights the difficulty of diagnosing tuberculous sinusitis in the absence of pulmonary foci. Although extrapulmonary localisations of tuberculosis are rare in immunocompetent patients, it is important to consider this diagnosis, since therapeutic delay usually results in an unfavourable outcome. Acid-fast bacilli are sometimes difficult to detect in pathological specimens. Consequently, the diagnosis is usually based on the following criteria: (i) the absence of clinical response to usual antibiotics, (ii) the presence of caseous granulomatous inflammatory lesion on histopathology, and (iii) identification of Mycobacterium tuberculosis by the polymerase chain reaction assay confirmed by bacteriological culture. The diagnosis of tuberculosis is finally confirmed by the efficacy of antituberculous treatment. The differential diagnosis is Wegener's disease.
本病例报告强调了在无肺部病灶情况下诊断结核性鼻窦炎的困难。尽管在免疫功能正常的患者中肺外结核定位罕见,但考虑这一诊断很重要,因为治疗延迟通常会导致不良后果。抗酸杆菌有时在病理标本中难以检测到。因此,诊断通常基于以下标准:(i)对常用抗生素无临床反应,(ii)组织病理学上存在干酪样肉芽肿性炎性病变,以及(iii)通过聚合酶链反应检测鉴定结核分枝杆菌并经细菌培养证实。结核病的诊断最终通过抗结核治疗的疗效得以确认。鉴别诊断为韦格纳肉芽肿病。