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通络蠲痹胶囊药效学研究

[Studies on pharmacodynamics of capsule tongluojuanbi].

作者信息

Li Li, Bai Lin, Zhang Yongzhong, Fang Jide

机构信息

Hubei Academy of Traditional Chinese Medicine and Pharmacy, Wuhan 430074.

出版信息

Zhong Yao Cai. 2002 Apr;25(4):278-80.

Abstract

OBJECTIVE

To study the pharmacological effects of Capsule Tongluojuanbi on antiinflammation and analgesic.

METHODS

To apply the rat model of adjuvant arthritis, classical experiment methods of antiinflammation and analgesic.

RESULTS

Capsule Tongluojuanbi obviously inhibited primary and secondary plantar swelling of adjuvant arthritis rats, tremendously relieved formaldehyde-induced arthritis in rats, reduced the inflammatory of mouse auricle, reduced the capillary permeability of mouse and diminished twisting reaction of abdominal cavity caused by injection of acetic acid.

CONCLUSION

Capsule Tongluojuanbi had obvious effect on antiinflammation and relieving pain.

摘要

目的

研究通络蠲痹胶囊的抗炎、镇痛药理作用。

方法

采用佐剂性关节炎大鼠模型,运用经典的抗炎、镇痛实验方法。

结果

通络蠲痹胶囊能明显抑制佐剂性关节炎大鼠原发性和继发性足跖肿胀,显著缓解大鼠甲醛性关节炎,减轻小鼠耳廓炎症,降低小鼠毛细血管通透性,并减少注射醋酸引起的腹腔扭体反应。

结论

通络蠲痹胶囊具有明显的抗炎、止痛作用。

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