[逐瘀胶囊对大鼠佐剂性关节炎的影响]
[The effects of zhubi capsule on adjuvant arthritis in rats].
作者信息
Li Hui, Jin Ya-hong, Yuan Gui-dong, Wang Su-fen
机构信息
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(7):551-4.
OBJECTIVE
To explore the therapeutic effects and mechanisms of Zhubi capsule on adjuvant arthritis (AA) in rats.
METHOD
The model of rat was induced by intradermal injection of CFA. The perimeter of ankle joint was measured at different time points. Con A-induced splencyte proliferation was examined by MIT assay and the expression of IL-1, IL-6 in synovium was determined by immunohistochemical method.
RESULT
After the preventive administration of Zhubi capsule (5.2, 2.6, 1.3 g x kg x d(-1), x 25 d), it was found that Zhubi capsule significantly inhibited the primary and secondary ankle joint swelling. The increased Con A-induced splencyte proliferation reaction and the activated IL1, IL-6 expression of AA rat were suppressed by the treatment with Zhubi capsule.
CONCLUSION
Zhubi capsule has a therapeutic effect on AA rats, and its mechanism is related to the immunoregulative function.
目的
探讨逐瘀胶囊对大鼠佐剂性关节炎（AA）的治疗作用及机制。
方法
采用皮内注射完全弗氏佐剂（CFA）诱导大鼠模型。在不同时间点测量踝关节周长。采用MTT法检测刀豆蛋白A诱导的脾细胞增殖，并用免疫组织化学方法测定滑膜中白细胞介素-1（IL-1）、白细胞介素-6（IL-6）的表达。
结果
预防性给予逐瘀胶囊（5.2、2.6、1.3 g·kg·d⁻¹，×25 d）后，发现逐瘀胶囊能显著抑制原发性和继发性踝关节肿胀。逐瘀胶囊治疗可抑制AA大鼠刀豆蛋白A诱导的脾细胞增殖反应增强及IL-1、IL-6表达激活。
结论
逐瘀胶囊对AA大鼠有治疗作用，其机制与免疫调节功能有关。
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