Liu Yonggang, Chen Houchang, Jiang Yiping
First Military Medical University, Guangzhou 510515.
Zhong Yao Cai. 2002 Jan;25(1):31-3.
To study the effect of tanshinone IIA on liver fibrosis in rats induced by CCl4.
Model of liver fibrosis in rats were induced by subcutaneous injection of CCl4 and malotilate was as positive control. The histological changes were observed with light microscope. The levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.
Tanshinone IIA could significantly reduce the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested tanshinone IIA has therapecuical effect on experimental liver fibrosis.
Tanshinone IIA may have therapeutical effect on CCL4-induced liver fibrosis in rats.
研究丹参酮ⅡA对四氯化碳诱导的大鼠肝纤维化的影响。
采用皮下注射四氯化碳诱导大鼠肝纤维化模型，以马洛替酯作为阳性对照。用光镜观察组织学变化。测定血清中谷丙转氨酶（ALT）、谷草转氨酶（AST）、一氧化氮（NO）、透明质酸（HA）、层粘连蛋白（LN）水平以及肝组织中羟脯氨酸（Hyp）、丙二醛（MDA）水平，以揭示肝脏损伤情况。
丹参酮ⅡA可显著降低血清中升高的ALT、AST、NO、HA、LN水平以及肝组织中Hyp、MDA水平。病理检查表明丹参酮ⅡA对实验性肝纤维化有治疗作用。
丹参酮ⅡA可能对四氯化碳诱导的大鼠肝纤维化有治疗作用。
