Gaynor James S, Brevard Sean, Mallinckrodt Craig, Baker Geri, Wander Kathy
Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Vet Ther. 2002 Winter;3(4):425-34.
A randomized, placebo-controlled, parallel study was conducted to investigate the effectiveness of oral carprofen for the control of postoperative pain in dogs undergoing knee surgery for stabilization of ruptured cranial cruciate ligaments. Dogs were randomly assigned to treatment with carprofen (n = 10) or placebo (n = 9). Pain was assessed at 1, 2, 4, 6, 24, and 48 hours and 10 and 21 days postoperatively. Eight of 10 dogs treated with carprofen and five of nine dogs treated with placebo were given at least one dose of morphine as rescue therapy. The mean relative dose of morphine given at 1 hour (P =.01) and 24 hours (P =.02) after surgery was greater for dogs treated with carprofen than for dogs given a placebo. There were no significant postoperative differences in cortisol levels or any measured variable. It appears that the scoring system used was not sensitive enough to detect differences in pain between a known analgesic and a placebo.
进行了一项随机、安慰剂对照、平行研究，以调查口服卡洛芬对因颅交叉韧带断裂进行膝关节手术的犬术后疼痛控制的有效性。犬被随机分配接受卡洛芬治疗（n = 10）或安慰剂治疗（n = 9）。在术后1、2、4、6、24和48小时以及10天和21天评估疼痛。接受卡洛芬治疗的10只犬中有8只和接受安慰剂治疗的9只犬中有5只至少接受了一剂吗啡作为救援治疗。术后1小时（P = 0.01）和24小时（P = 0.02），接受卡洛芬治疗的犬给予的吗啡平均相对剂量高于给予安慰剂的犬。术后皮质醇水平或任何测量变量均无显著差异。看来所使用的评分系统不够敏感，无法检测出已知镇痛药和安慰剂之间的疼痛差异。
