Reese C J, Trotter E J, Short C E, Erb H N, Barlow L L
Companion Animal Hospital, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
J Am Anim Hosp Assoc. 2000 Sep-Oct;36(5):448-55. doi: 10.5326/15473317-36-5-448.
Twenty-one otherwise healthy dogs that presented for surgical repair of a ruptured cranial cruciate ligament were blindly and randomly given either carprofen (2.2 mg/kg body weight, orally) or a placebo beginning 12 hours preoperatively and continuing every 12 hours for a total of three doses. The patients were assessed for postoperative pain using a subjective pain score and given oxymorphone (0.1 mg/kg body weight, intramuscularly) every four hours if the pain score was 2 or greater. Blood samples were also collected to determine serum cortisol levels. There was a significant increase in serum cortisol levels in the immediate postoperative period in both the placebo group and the carprofen group (p less than 0.05). There was no significant difference in the percentage of increase in serum cortisol levels between the two groups. No correlation was evident between the serum cortisol levels and the corresponding pain scores in either group. This subjective method of assessing postoperative pain was not accurate and should not be relied upon for determination of postoperative analgesic administration. Perioperative oral administration of carprofen did not appear to be effective in controlling postoperative pain in these patients.
21只原本健康的犬因颅交叉韧带断裂前来接受手术修复，从术前12小时开始，被随机盲法给予卡洛芬（2.2毫克/千克体重，口服）或安慰剂，每12小时给药一次，共给药三次。使用主观疼痛评分对患者的术后疼痛进行评估，如果疼痛评分为2或更高，则每四小时给予羟吗啡酮（0.1毫克/千克体重，肌肉注射）。还采集血样以测定血清皮质醇水平。安慰剂组和卡洛芬组术后即刻血清皮质醇水平均显著升高（p小于0.05）。两组血清皮质醇水平升高的百分比无显著差异。两组中血清皮质醇水平与相应疼痛评分之间均无明显相关性。这种主观评估术后疼痛的方法不准确，不应依赖其来确定术后镇痛药物的使用。围手术期口服卡洛芬似乎对控制这些患者的术后疼痛无效。
