Wang Shuo, Wang Shuo-ren, Zhao Yue-ru
Dongzhimen Hospital Affiliated to Beijing TCM University, Beijing 100700.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Apr;22(4):274-6.
To study the effect of Jiangya Tongmai Recipe (JYTMR), a Chinese herbal medicine preparation for activating blood circulation to remove stasis, on vascular activating substances in treating patients of hypertension with left ventricular hypertrophy.
The 37 patients with hypertension were randomly divided into two groups, the treated group (n = 21) and the control group (n = 16). They were treated with JYTMR and captopril respectively for 8 weeks. Left ventricular mass weight (LVMI), peak flow velocity of early diastole (Emax), peak flow velocity of atrial contraction (Amax), Emax/Amax, ejection fraction (EF), as well as levels of plasma endothelin (ET), calcitonin gene-related peptide (CGRP) and angiotensin II (Ang II) were measured before and after treatment and compared.
JYTMR could enhance the left ventricular dilation and contractile functions, lower the levels of plasma ET and Ang II and increase the level of plasma CGRP.
JYTMR shows good effect in improving left ventricular function and regulating vascular activating substances, it could prevent and treat hypertension and its complications for prolonged treatment via multiple paths and links.
研究具有活血化瘀功效的中药制剂降压通脉方（JYTMR）对高血压合并左心室肥厚患者血管活性物质的影响。
将37例高血压患者随机分为两组，治疗组（n = 21）和对照组（n = 16）。分别给予降压通脉方和卡托普利治疗8周。测量治疗前后左心室质量重量（LVMI）、舒张早期峰值流速（Emax）、心房收缩峰值流速（Amax）、Emax/Amax、射血分数（EF），以及血浆内皮素（ET）、降钙素基因相关肽（CGRP）和血管紧张素II（Ang II）水平并进行比较。
降压通脉方可增强左心室舒张和收缩功能，降低血浆ET和Ang II水平，提高血浆CGRP水平。
降压通脉方在改善左心室功能和调节血管活性物质方面显示出良好效果，通过多条途径和环节长期治疗可防治高血压及其并发症。
