Traditional Uighur Medicine Institute, Xinjiang Medical University, 830011 Urumqi, Xinjiang, PR China.
BMC Complement Altern Med. 2014 Jan 21;14:36. doi: 10.1186/1472-6882-14-36.
Dioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. The objective of this study was to investigate the possible antihypertensive effects of the aqueous extract of (DOT) in renovascular hypertensive rats as well as the mechanism in reducing blood pressure.
The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. Rats with captopril, low-dose DOT and high-dose DOT treated 2K1C groups for 6 weeks. The blood pressure, cardiac mass index (heart weight/body weight), plasma level of angiotensin-II (Ang-II), endothelin-1(ET-1), superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated.
DOT significantly reduced mean systolic and diastolic blood pressure after treatment. DOT also significantly increased plasma SOD activity but decreased plasma MDA concentration. Renal function was improved with captopril and DOT. DOT reduced plasma Ang-II activity and plasma ET concentration. They couldalso significantly reduce the left ventricular hypertrophy and cardiac mass index.
Our results suggest that DOT may have an antihypertensive effect on hypertension by inhibit ET-converting enzyme and antioxidant activity, which warrant further exploration.
薯蓣（怀山药，DOT）是中国常见的主食，在中国传统医学（TCM）中已使用了 2000 多年，用于治疗包括高血压在内的各种系统性疾病。本研究旨在探讨（DOT）水提物对肾血管性高血压大鼠的可能降压作用及其降压机制。
采用两肾一夹（2K1C）Goldblatt 型肾血管性高血压大鼠模型。用卡托普利、低剂量 DOT 和高剂量 DOT 治疗 2K1C 组 6 周。评估血压、心脏质量指数（心脏重量/体重）、血管紧张素-II（Ang-II）、内皮素-1（ET-1）、超氧化物歧化酶（SOD）和丙二醛（MDA）的血浆水平。
DOT 治疗后显著降低了平均收缩压和舒张压。DOT 还显著增加了血浆 SOD 活性，降低了血浆 MDA 浓度。卡托普利和 DOT 改善了肾功能。DOT 降低了血浆 Ang-II 活性和 ET 浓度。它们还可以显著减少左心室肥厚和心脏质量指数。
我们的结果表明，DOT 可能通过抑制 ET 转换酶和抗氧化活性对高血压具有降压作用，这值得进一步探索。
