T细胞作为针对疟原虫肝期的保护性免疫介质。

T cells as mediators of protective immunity against liver stages of Plasmodium.

作者信息

Tsuji Moriya, Zavala Fidel

机构信息

Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.

出版信息

Trends Parasitol. 2003 Feb;19(2):88-93. doi: 10.1016/s1471-4922(02)00053-3.

DOI:10.1016/s1471-4922(02)00053-3

PMID:12586477

Abstract

T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (alphabeta CD8(+) and CD4(+) T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. gammadelta and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the alphabeta T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.

摘要

来自不同亚群的T细胞在针对疟原虫前体红细胞阶段的保护性免疫中起主要作用。人类和动物接触疟原虫子孢子会诱导产生针对疟原虫前体红细胞阶段表达抗原的αβ CD8⁺和CD4⁺ T细胞。这些T细胞抑制肝脏中的寄生虫发育，用表达相应抗原部分的亚单位疫苗进行免疫可提供针对子孢子攻击的保护。γδ和自然杀伤T细胞也可在保护性免疫中发挥作用。最近对αβ T细胞受体转基因小鼠的研究揭示了调节这些反应诱导和发展的复杂机制的存在。