纤维肌痛中色氨酸代谢改变的证据。

Evidence for an altered tryptophan metabolism in fibromyalgia.

作者信息

Schwarz M J, Offenbaecher M, Neumeister A, Ewert T, Willeit M, Praschak-Rieder N, Zach J, Zacherl M, Lossau K, Weisser R, Stucki G, Ackenheil M

机构信息

Psychiatric Hospital, University of Munich, D-80336, Munich, Germany.

出版信息

Neurobiol Dis. 2002 Dec;11(3):434-42. doi: 10.1006/nbdi.2002.0563.

DOI:10.1006/nbdi.2002.0563

PMID:12586552

Abstract

Fibromyalgia (FM) is a prevalent syndrome with chronic pain and a hypothesized underlying disturbance of the tryptophan (TRP) metabolism. We performed a tryptophan depletion (TD) test in 17 FM patients and 17 controls. TRP, 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), and interleukin-6 (IL-6) were measured. Additionally pain perception was monitored in the FM patients. FM patients and controls exhibited a decrease of TRP and KYN during TD. 5-HIAA levels also decreased in all controls and in 11 FM patients, but showed a marked increase in 6 FM patients. IL-6 significantly increased during TD in the patients, but not in the controls. Pain perception was not affected in the FM patients. These data demonstrate an altered TRP metabolism in a subgroup of FM patients, where the TD seems to activate 5-HT metabolism. Our findings may have diagnostic as well as therapeutic implications in the field of fibromyalgia.

摘要

纤维肌痛（FM）是一种常见的综合征，伴有慢性疼痛，并且存在色氨酸（TRP）代谢潜在紊乱的假说。我们对17例FM患者和17名对照者进行了色氨酸耗竭（TD）试验。检测了TRP、5-羟吲哚乙酸（5-HIAA）、犬尿氨酸（KYN）和白细胞介素-6（IL-6）。此外，还对FM患者的疼痛感知进行了监测。FM患者和对照者在TD期间TRP和KYN均降低。所有对照者以及11例FM患者的5-HIAA水平也降低，但6例FM患者的5-HIAA水平显著升高。患者在TD期间IL-6显著升高，而对照者则未升高。FM患者的疼痛感知未受影响。这些数据表明，在一部分FM患者中TRP代谢发生了改变，其中TD似乎激活了5-羟色胺（5-HT）代谢。我们的研究结果可能对纤维肌痛领域的诊断和治疗具有重要意义。