果蝇杂交种中一种新的育性拯救系统揭示了杂种致死与雌性不育之间的联系。
A novel system of fertility rescue in Drosophila hybrids reveals a link between hybrid lethality and female sterility.
作者信息
Barbash Daniel A, Ashburner Michael
机构信息
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
出版信息
Genetics. 2003 Jan;163(1):217-26. doi: 10.1093/genetics/163.1.217.
Abstract
Hybrid daughters of crosses between Drosophila melanogaster females and males from the D. simulans species clade are fully viable at low temperature but have agametic ovaries and are thus sterile. We report here that mutations in the D. melanogaster gene Hybrid male rescue (Hmr), along with unidentified polymorphic factors, rescue this agametic phenotype in both D. melanogaster/D. simulans and D. melanogaster/D. mauritiana F(1) female hybrids. These hybrids produced small numbers of progeny in backcrosses, their low fecundity being caused by incomplete rescue of oogenesis as well as by zygotic lethality. F(1) hybrid males from these crosses remained fully sterile. Hmr(+) is the first Drosophila gene shown to cause hybrid female sterility. These results also suggest that, while there is some common genetic basis to hybrid lethality and female sterility in D. melanogaster, hybrid females are more sensitive to fertility defects than to lethality.
摘要
黑腹果蝇雌性与拟果蝇物种分支的雄性杂交产生的杂种雌性后代在低温下完全可存活，但卵巢无配子，因此不育。我们在此报告，黑腹果蝇杂交雄性拯救基因（Hmr）的突变，以及未鉴定的多态性因子，可拯救黑腹果蝇/拟果蝇和黑腹果蝇/毛里求斯果蝇F(1)雌性杂种中的这种无配子表型。这些杂种在回交中产生少量后代，其低繁殖力是由卵子发生的不完全拯救以及合子致死率导致的。这些杂交产生的F(1)杂种雄性仍然完全不育。Hmr(+)是第一个被证明导致杂种雌性不育的果蝇基因。这些结果还表明，虽然黑腹果蝇中杂种致死和雌性不育存在一些共同的遗传基础，但杂种雌性对生育缺陷比致死更敏感。
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