Mameli S, Frau L, Orrù A, Marchi A, Corbucci G G
Servizio Terapia Antalgica, Ospedale Businco, ASL n. 8, Cagliari, Italy.
Minerva Anestesiol. 2002 Dec;68(12):919-29.
Incident pain does not respond to opioid treatment and it is not easily relieved with other therapeutic strategies (local intrapleural or spinal analgesia, phenol blocks etc.). For this reason cervical percutaneous cordotomy at C(1)-C(2) interspace is the only effective antalgic therapy in patients whose life expectancy is more than three to six months.
This study is a rectrospective review of 22 patients with cancer and incident pain from brachial, lumbar-sacral plexus injury and gluteal ulcer.
Cordotomy provided excellent contralateral side pain relief in 21 patients; pain relief was maintained up to death and to the moment of last observation in living patients. In one deaf patient it was impossible to carry out the procedure due to incomplete co-operation and pain returned after 48 hours. Ventilatory depression caused death in one patient. Other complications recorded included ataxia, headache, motor deficit, dysesthesia and orthostatic hypotension.
The conclusion is drawn that percutaneous cordotomy should, in carefully selected cases, be considered the only technique to relieve incident pain.
突发性疼痛对阿片类药物治疗无反应,且难以通过其他治疗策略(局部胸膜内或脊髓镇痛、酚阻滞等)缓解。因此,对于预期寿命超过三至六个月的患者,C(1)-C(2)间隙的颈椎经皮脊髓切开术是唯一有效的镇痛疗法。
本研究是对22例患有癌症且因臂丛、腰骶丛损伤和臀溃疡导致突发性疼痛的患者进行的回顾性研究。
脊髓切开术使21例患者对侧疼痛得到极佳缓解;疼痛缓解一直持续到患者死亡以及存活患者的最后观察时刻。在一名失聪患者中,由于合作不充分无法进行该手术,48小时后疼痛复发。一名患者因呼吸抑制死亡。记录的其他并发症包括共济失调、头痛、运动功能障碍、感觉异常和体位性低血压。
得出的结论是,在经过仔细挑选的病例中,经皮脊髓切开术应被视为缓解突发性疼痛的唯一技术。