Tsou Paul M, Alan Yeung Christopher, Yeung Anthony T
1245 16th Street, #202, Santa Monica, CA 90404, USA.
Spine J. 2004 Sep-Oct;4(5):564-73. doi: 10.1016/j.spinee.2004.01.014.
BACKGROUND CONTEXT: Chronic lumbar discogenic pain (CLDP) impairs the patient's physical abilities to function within the normal physiologic loading ranges of activities of daily living. The pathogenesis of CLDP is multifactorial and not well understood. Conservative therapeutic regimens often fail to achieve sufficient pain relief. Surgical options vary greatly in surgical invasiveness as well as outcome. Definitive surgical treatment is often 360-degree fusion. The morbidity associated with this approach is significant, considering that only 65% to 80% of patients obtain satisfactory clinical results. This has spawned interest in minimally invasive surgical options, such as intradiscal electrothermal therapy (IDET; ORATEC Interventions, Inc., Menlo Park, CA), but results are conflicting. PURPOSE: The authors describe their surgical technique of minimal access posterolateral transforaminal selective endoscopic discectomy (SED) and bipolar radiofrequency thermal annuloplasty to treat CLDP. The procedure's rationale is based on the hypothesis that annular defects are the focal points of chronic exposure between neural sensory receptors in the defect and the inflammatogenic nucleus pulposus. In contrast to other percutaneous procedures, this technique allows direct visualization and targeting of the disc nucleus and annular fissures. Our 2-year clinical result is reported. STUDY DESIGN/SETTING: This is a retrospective review of consecutive surgical cases performed by one surgeon (ATY). The procedures were carried out from January 1997 to December 1999. Each patient has a minimum postoperative follow-up of 2 years. PATIENT SAMPLE: A total of 113 patients met the generally accepted clinical criteria for chronic lumbar discogenic pain and were selected for the procedure. OUTCOME MEASURES: Two outcome measures were used for clinical assessment: a surgeon-based modified MacNab method and a patient-based questionnaire. A mandatory poor result was given to any patient who had repeat spine surgery at the same level or has indicated dissatisfaction with the surgical result on the questionnaire response. METHOD: After meeting CLDP selection criteria, provocation contrast/indigo carmine dye discography was performed. This test was used to confirm the suspected discs as pain generators. The subject surgery then followed. Only cases with one and two levels of confirmed painful discs were entered into the study. The nonoperating author (PMT) analyzed the data. RESULTS: Using the surgeon assessment method, 17 patients (15%) had excellent results, 32 patients (28.3%) had good results, 34 patients (30.1%) had fair results and 30 patients (26.5%) had poor results. Of the 30 patients in the poor result group, 12 reported either no improvement or worsening, and refused further surgical treatment. Of the remaining 18 patients in the poor group, 8 had spinal fusion, 3 had laminectomy and 7 had repeat spinal endoscopic surgery. The patient-based questionnaire yielded similar percentages in each category. However, only 73.5% of the 113 patients returned the survey questionnaire. There were no aborted procedures, unexpected hemorrhage, device-related complications, neurologic deficits, perioperative deaths or late instability. CONCLUSIONS: Posterolateral transforaminal SED and radiofrequency thermal annuloplasty were used to interrupt the purported annular defect pain sensitization process, thought to be necessary in the genesis of chronic lumbar discogenic pain. Lack of clinical benefit from the subject procedure did not degrade any subsequent surgical or nonsurgical treatment options. The experience gained from this study warrants further investigation into the cellular and molecular processes that provided back pain relief in these patients.
背景:慢性腰椎间盘源性疼痛(CLDP)会损害患者在日常生活正常生理负荷范围内的身体功能。CLDP的发病机制是多因素的,目前尚未完全明确。保守治疗方案往往无法充分缓解疼痛。手术选择在手术侵入性和效果方面差异很大。确定性手术治疗通常是360度融合术。考虑到只有65%至80%的患者能获得满意的临床效果,这种方法的发病率很高。这引发了人们对微创外科手术选择的兴趣,如椎间盘内电热疗法(IDET;ORATEC Interventions公司,加利福尼亚州门洛帕克),但其结果存在争议。 目的:作者描述了他们采用微创后外侧经椎间孔选择性内镜下椎间盘切除术(SED)和双极射频热凝纤维环成形术治疗CLDP的手术技术。该手术的理论基础是基于这样的假设,即纤维环缺损是缺损处神经感觉受体与致炎髓核之间慢性接触的焦点。与其他经皮手术不同,该技术允许直接观察和定位椎间盘髓核及纤维环裂隙。报告了我们的2年临床结果。 研究设计/地点:这是对一位外科医生(ATY)连续进行的手术病例的回顾性研究。手术于1997年1月至1999年12月进行。每位患者术后至少随访2年。 患者样本:共有113例患者符合慢性腰椎间盘源性疼痛的公认临床标准,并被选入该手术。 结果测量:采用两种结果测量方法进行临床评估:基于外科医生的改良MacNab方法和基于患者的问卷调查。任何在同一节段进行过二次脊柱手术或在问卷调查中表示对手术结果不满意的患者均被判定为手术效果差。 方法:在符合CLDP选择标准后,进行激发对比/靛胭脂椎间盘造影。该检查用于确认可疑椎间盘为疼痛源。然后进行手术。仅将有1个和2个节段确诊为疼痛性椎间盘的病例纳入研究。非手术作者(PMT)分析数据。 结果:采用外科医生评估方法,17例患者(15%)效果极佳,32例患者(28.3%)效果良好,34例患者(30.1%)效果一般,30例患者(26.5%)效果差。在效果差的30例患者中,12例报告无改善或病情恶化,并拒绝进一步手术治疗。在效果差的其余18例患者中,8例行脊柱融合术,3例行椎板切除术,7例行重复脊柱内镜手术。基于患者的问卷调查在各分类中得出了相似的百分比。然而,113例患者中只有73.5%返回了调查问卷。没有手术中止、意外出血、与器械相关的并发症、神经功能缺损、围手术期死亡或晚期不稳定情况。 结论:后外侧经椎间孔SED和射频热凝纤维环成形术用于中断据称的纤维环缺损疼痛致敏过程,该过程被认为是慢性腰椎间盘源性疼痛发生所必需的。该手术缺乏临床益处并未降低任何后续手术或非手术治疗选择。从本研究中获得的经验值得进一步研究为这些患者缓解背痛的细胞和分子过程。
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009-4
J Korean Neurosurg Soc. 2025-9
Spinal Cord Ser Cases. 2023-8-12