Vázquez García Juan Carlos
Departamento de Fisiología Respiratoria, Instituto Nacional de Enfermedades Respiratorias, INER, México, D.F., México.
Rev Invest Clin. 2002 Sep-Oct;54(5):453-61.
Obesity and asthma are two disorders of high and increasing worldwide prevalence. A consistent association between obesity and asthma has been recently found in case-control, cross-sectional and longitudinal studies. This association is more consistent in women after the puberty. Moreover, an improvement in the severity of asthma has been described after weight reduction in obese patients. A causal association between asthma and obesity may represent an additional respiratory work that could increase the morbidity and medical expenditures. The most striking studies which demonstrate association between obesity and asthma and the possible causal mechanisms are reviewed.
肥胖和哮喘是两种在全球范围内患病率高且呈上升趋势的疾病。最近在病例对照研究、横断面研究和纵向研究中发现肥胖与哮喘之间存在持续关联。这种关联在青春期后的女性中更为一致。此外,已有报道称肥胖患者体重减轻后哮喘严重程度有所改善。哮喘与肥胖之间的因果关联可能意味着额外的呼吸负担,这可能会增加发病率和医疗费用。本文综述了最具代表性的关于肥胖与哮喘关联及可能因果机制的研究。