Saxena A, Dyker K M, Angel S, Moshynska O, Dharampaul S, Cockroft D W
Department of Pathology, Royal University Hospital, Saskatoon SK S7 N OW8, Canada.
Virchows Arch. 2002 Dec;441(6):622-8. doi: 10.1007/s00428-002-0694-x.
The exact relationship between lymphomatoid granulomatosis (LyG) and posttransplant lymphoproliferative disorders (PTLDs) is not clear. Both are observed in immunodeficient patients and are Epstein-Barr virus driven. These disorders are, however, considered distinct based upon the immune response elicited; LyG is T-cell rich while PTLDs are T-cell poor. We describe a case of LyG-type diffuse large B-cell lymphoma (DLBCL) in a lung transplant recipient. The unusual features include rare occurrence of LyG in a posttransplant setting, systemic involvement by LyG variant of DLBCL in a solid organ transplant recipient, paucity of T-cells in this LyG type lymphoma, and subcutaneous panniculitic pattern in a B-cell lymphoproliferative disorder. This first report of systemic LyG variant of DLBCL in a posttransplant setting has features suggesting similarities and overlap between LyG and PTLD.
淋巴瘤样肉芽肿病（LyG）与移植后淋巴增殖性疾病（PTLD）之间的确切关系尚不清楚。二者均见于免疫缺陷患者，且均由爱泼斯坦-巴尔病毒驱动。然而，基于引发的免疫反应，这些疾病被认为是不同的；LyG富含T细胞，而PTLDs缺乏T细胞。我们描述了一例肺移植受者发生的LyG型弥漫性大B细胞淋巴瘤（DLBCL）。其不寻常的特征包括：LyG在移植后环境中罕见，实体器官移植受者中DLBCL的LyG变异型出现全身累及，此LyG型淋巴瘤中T细胞稀少，以及B细胞淋巴增殖性疾病中的皮下脂膜炎样模式。这篇关于移植后环境中DLBCL的系统性LyG变异型的首例报告具有一些特征，提示LyG与PTLD之间存在相似性和重叠。
